The PIA passenger plane PK 116 was enroute to Islamabad from the northern city of Chitral, when it lost contact with the air traffic control.
"PIA's ATR-42 aircraft operating as PK-661, carrying around 40 persons lost its contact with the control tower on its way from Chitral to Islamabad a short while ago," PIA spokesman Daniyal Gilani tweeted.
"All resources are being mobilised to locate the aircraft."
A PIA aircraft has lost contact with control tower. Plz see statement below.
— Danyal Gilani (@Danyal_Gilani) December 7, 2016
Pakistani media - Geo News and Dawn News have reported that there 47 people were on board the aircraft.
The plane reportedly lost contact with civil aviation authority at around 4.30pm (11.30 GMT).