Keerthy Suresh then debuted in Tamil cinema and acted in several films like Rajini Murugan, Remo, Bairavaa, and Thaanaa Serndha Koottam. She quickly became paired with leading actors like Vijay, Surya, and Dhanush. However, the turning point in her career was Mahanati, the biopic of actress Savitri. Her performance amazed everyone, earning her the National Award for Best Actress.