The sixth seed dominated Yip Pui Yin of Hong Kong in straight games, 21-9 29-27 in the opening round of the Super Series tournament, that lasted only 45 minutes.
While the first game was one-sided as the scoreline shows, Pui Yin gave a superb fight back and finally had answers to Sindhu's powerful smashes and tricky movements. Eventually, the Indian edged her opponent by two points.
Sindhu's next opponent in the ongoing Super Series is China's 19-year-old He BJ.
With the top three seeds, Carolina Marlin, Ratchanok Intanon and Nozomi Okuhara, withdrawn from the tournament, Sindhu who bagged a silver medal at the Rio Olympics earlier, has a great chance to finally break the jinx.
The Hyderabadi badminton player is yet to win a Badminton World Federation (BWF) Super Series title.
In men's singles, HS Prannoy defeated Thailand's Boonsak Ponsana 21-16 21-18 to enter the second round of the tournament. Meanwhile, Ajay Jayaram and Sai Parneeth will take on their respective opponents later in the day.