The company's plans include a 55% reduction in force and exploring strategic alternatives such as out-licensing, mergers, or asset sales.
Shares of Vincerx Pharma saw volatile trading on Wednesday, swinging between gains and losses after the company unveiled significant cost-cutting measures.
The moves are aimed at advancing its VIP943 program, a cancer treatment for leukemias and myelodysplastic syndrome, the company said.
Vincerx CEO Ahmed Hamdy reiterated the company’s commitment to VIP943, highlighting positive early results from the Phase 1 dose-escalation study.
The trial showed promising safety and efficacy, with a relapsed AML patient achieving complete remission with incomplete blood count recovery (CRi) and a higher-risk MDS patient achieving complete remission with leukemic cells (CRL).
Notably, the CRi patient showed significant improvement, with their bone marrow revealing only 1% cancer cells after seven months.
To ensure the continued development of VIP943, Vincerx is taking aggressive steps to streamline operations and focus resources on the trial’s advancement.
That includes a 55% reduction in force and exploring strategic alternatives such as out-licensing, mergers, or asset sales.
The company also announced plans to engage a financial advisor to guide the strategic review process.
Retail activity surrounding VINC surged, with message volume on Stocktwits reaching the second-highest level in the past year, while sentiment remained ‘bullish’.
One watcher speculated that a reverse stock split or partnership deal could be in the works.
Vincerx’s stock has struggled, losing over 75% of its value year-to-date.
As of Oct. 31, the company had $8.4 million in cash and is actively pursuing partnerships to advance other oncology treatments, including VIP236 for solid tumors and enitociclib for leukemia.
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